higher organisms such as vertebrates have a developed brain. These results demonstrate that dendrites retain regenerative potential throughout adulthood and that regenerative capacity decreases with aging. The nervous system or the neural system is a complex network of neurons specialized to. Finally, inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration. Furthermore, we found that the regenerated dendrites show preferential alignment with the extracellular matrix (ECM). Regenerated dendrites recovered receptive function. We found that the capacity for regeneration was present in adult neurons but diminished as the animal aged. The information transfer is usually received at the dendrites through. The transfer of information from one neuron to another is achieved through chemical signals and electric impulses, that is, electrochemical signals. Using a laser severing paradigm, we monitored regeneration after acute and spatially restricted injury. Dendrites are projections of a neuron (nerve cell) that receive signals (information) from other neurons. which has a dendritic arbor that undergoes dramatic remodeling during the first 3 d of adult life and then maintains a relatively stable morphology thereafter. One potential target for therapeutic interventions is brainderived neurotrophic factor (BDNF), known to promote neuronal growth and survival and decrease in aging (Binder & Scharfman, et al ). This study characterizes the structural and functional capacity for dendrite regeneration in vivo in adult animals and examines the effect of neuronal maturation on dendrite regeneration. Developing approaches aimed at promoting neurogenesis and/or dendritic morphology is necessary. The focus of this work is on the ability of neurons to regenerate dendrites. Aspects of dendrite development in adulthood were also examined, including the function of c4da neuron in the adult abdomen and the source of extracellular matrix in the abdomen. Candidates for further study were identified. While the collagen a'py-3 has not been implicated in neural development, the glypican heparan sulphate proteoglycan lon-2 has been implicated in axon. Therefore, a screen for kinesins which regulate dendritic arbor complexity was performed. Although molecular motors are known to play a role in the development of the dendritic arbor, there was not a comprehensive understanding of kinesins in dendrite development. We focused on the class IV dendritic arborization (c4da) neuron of the Drosophila sensory system to address aspects of dendrite development and regeneration due to the complex dendritic arbor and peripheral location of these neurons. Despite their key role in neuronal function, current understanding of dendrite development and regeneration are lacking.
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